Different Forms of Primary Immunodeficiency

Primary immunodeficiencies are complex diseases. Since each one can be traced to the failure of one or more parts of the immune system, one of the more convenient ways to group them is according to the part of the immune system that is faulty:

• B cell (antibody) deficiencies
• combined T cell and b cell (antibody) deficiencies
• T cell deficiencies
• defective phagocytes
• complement deficiencies
• deficiencies/cause unknown
• More than half of all PID's are caused by a lack of infection fighting antibodies (immunoglobulins). The person who has either too few antibody producing B cells or B cells that don't work properly.
• X-Linked Agammaglobulinemia (XLA)
• Common Variable Immunodeficiency
• Hyper IgM Syndrome
• Selective IgA Deficiency
• IgG Subclass Deficiency
• Severe Combined Immunodeficiency (SCID)
• Partial Combined Deficiencies
• Wiskott-Aldrich Syndrome (WAS)
• Ataxia-Telangiectasia (AT)

T Cell Deficiencies

• DiGeorge Anomaly
• Cartilage Hair Hypoplasia

Defective Phagocytes

• Chronic Granulomatous Disease (CGD)
• Leukocyte Adhesion Defect (LAD)
• Chediak-Higashi Syndrome (CHS)

Complement Deficiencies
Deficiencies/Cause Unknown

• Hyper-IgE Syndrome
• Chronic Mucocutaneous Candidiasis